Methoxphenidine

Source: Wikipedia, the free encyclopedia.
Methoxphenidine
Clinical data
Routes of
administration		Oral, Rectal
Legal status
Legal status
Identifiers
  • (±)-1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine
JSmol)
  • COC1=C(C=CC=C1)C(CC2=CC=CC=C2)N3CCCCC3
  • InChI=1S/C20H25NO/c1-22-20-13-7-6-12-18(20)19(21-14-8-3-9-15-21)16-17-10-4-2-5-11-17/h2,4-7,10-13,19H,3,8-9,14-16H2,1H3
  • Key:QXXCUXIRBHSITD-UHFFFAOYSA-N

Methoxphenidine (methoxydiphenidine, 2-MeO-Diphenidine, MXP) is a

dissociative of the diarylethylamine class that has been sold online as a designer drug.[1][2] Methoxphenidine was first reported in a 1989 patent where it was tested as a treatment for neurotoxic injury.[3] Shortly after the 2013 UK ban on arylcyclohexylamines methoxphenidine and the related compound diphenidine became available on the gray market, where it has been encountered as a powder and in tablet form.[4] Though diphenidine possesses higher affinity for the NMDA receptor, anecdotal reports suggest methoxphenidine has greater oral potency.[1] Of the three isomeric anisyl-substituents methoxphenidine has affinity for the NMDA receptor that is higher than 4-MeO-Diphenidine but lower than 3-MeO-Diphenidine,[3][5] a structure–activity relationship shared by the arylcyclohexylamines.[6]

Side effects

Acute methoxphenidine intoxication has been reported to produce confusion, hypertension, and tachycardia that was responsive to treatment with intravenous lorazepam,[7][8] methoxphenidine has also been associated with three published fatalities[9] and one case of impaired driving.[10]

Psychotic episodes have also been reported, including a murder in June 2014.[11]

Legal status

As of October 2015 MXP is a controlled substance in China.[12]

MXP is also banned in Sweden.[13]

In Canada, MT-45 and its analogues were made Schedule I controlled substances, which includes DPD[clarification needed] in its structural group.[14] Possession without legal authority can result in maximum seven years imprisonment. Further, Health Canada amended the Food and Drug Regulations in May, 2016 to classify explicitly DPD as a restricted drug. Only those with a law enforcement agency, person with an exemption permit or institutions with Minister's authorization may possess the drug.

See also

References

  1. ^
    PMID 24678061
    .
  2. S2CID 6204908
    .
  3. ^ a b EP 0346791, Gray NM, Cheng BK, "1,2-diarylethylamines for treatment of neurotoxic injury", issued 6 April 1994, assigned to GD Searle LLC 
  4. S2CID 33626099. Archived
    (PDF) from the original on 2020-03-09. Retrieved 2021-05-31.
  5. PMID 29642450
    .
  6. PMID 27314670
    .
  7. S2CID 8513947. Archived
    (PDF) from the original on 2021-05-31. Retrieved 2021-05-31.
  8. S2CID 5962038
    .
  9. PMID 25698777
    .
  10. S2CID 6483817
    .
  11. ^ "Man who killed mother believing her to be a witch sentenced to minimum of five years in jail". BBC News. 17 June 2016. Archived from the original on 24 August 2020. Retrieved 31 May 2021.
  12. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" [Notice on Issuing the Measures for the Listing and Control of Non-Medicinal Narcotic Drugs and Psychotropic Substances] (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
  13. ^ "Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 24 March 2015. Archived from the original on 24 September 2015. Retrieved 21 October 2015.
  14. ^ Arsenault D (1 June 2016). "Regulations Amending the Food and Drug Regulations (Parts G and J — Lefetamine, AH-7921, MT-45 and W-18)". Canada Gazette. 150 (11). Archived from the original on 2017-12-02. Retrieved 2016-11-17.
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