Trimethoxyamphetamine
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Trimethoxyamphetamines (TMAs) are a family of
The most important TMA compound from a pharmacological standpoint is TMA-2, as this isomer has been much more widely used as a recreational drug and sold on the grey market as a so-called research chemical; TMA (sometimes referred to as "mescalamphetamine" or TMA-1) and TMA-6 have also been used in this way to a lesser extent. These three isomers are significantly more active as hallucinogenic drugs, and have consequently been placed onto the illegal drug schedules in some countries such as the Netherlands and Japan. The other three isomers TMA-3, TMA-4, and TMA-5 are not known to have been used as recreational drugs to any great extent.
TMAs
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Note: Because they are isomers, the TMAs have the same chemical formula, C12H19NO3, and the same molecular mass, 225.28 g/mol.
Properties
Compound | Pattern | Dose | Duration |
---|---|---|---|
TMA | 3,4,5 | 100 – 250 mg | 6 - 8 h |
TMA-2 | 2,4,5 | 20 – 40 mg | 8 - 12 h |
TMA-3 | 2,3,4 | > 100 mg | unknown |
TMA-4 | 2,3,5 | > 80 mg | ~ 6 h |
TMA-5 | 2,3,6 | ≥ 30 mg | 8 - 10 h |
TMA-6 | 2,4,6 | 25 – 50 mg | 12 - 16 h |
Legality
Brazil
It is scheduled in the F2 class (prohibited psychotropics) of the Brazilian Controlled Drugs and Substances Act.[2]
Sweden
Sveriges riksdag added TMA-2 to schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of Dec 30, 1999, published by Medical Products Agency in their regulation LVFS 2004:3 listed as 2,4,5-trimetoxiamfetamin (TMA-2).[3]
United Kingdom
Illegal under the Psychoactive Substances Act 2016
United States of America
3,4,5-Trimethoxyamphetamine is listed as a Schedule 1 controlled substance, along with positional isomers 2,4,5-Trimethoxyamphetamine (TMA-5), 2,4,6-Trimethoxyamphetamine (TMA-6) and Escaline. [4]
See also
- Mescaline
- Hallucinogenic drug
- Amphetamine
References
- PMID 20260568.
- ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
- ^ http://www.lakemedelsverket.se/upload/lvfs/LVFS_2004-3.pdf [bare URL PDF]
- ^ https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf