4-HO-DiPT

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4-HO-DiPT
Clinical data
Routes of
administration		Oral
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
  • UK:
    Class A
  • US: Unscheduled
Pharmacokinetic data
Duration of action2–3 hours[1]
Identifiers
  • 3-[2-(diisopropylamino)ethyl]-1H-indol-4-ol
JSmol)
SMILES
  • CC(C)N(CCc1c[nH]c2cccc(O)c12)C(C)C
  • InChI=1S/C16H24N2O/c1-11(2)18(12(3)4)9-8-13-10-17-14-6-5-7-15(19)16(13)14/h5-7,10-12,17,19H,8-9H2,1-4H3 checkY
  • Key:KBRYKXCBGISXQV-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

4-HO-DiPT, also known as 4-hydroxy-N,N-diisopropyltryptamine or as iprocin, is a

positional isomer of 4-HO-DPT
.

Dosage

In

duration
of its effects significantly.

Effects

The effects of 4-HO-DiPT are broadly comparable to those of other serotonergic psychedelics such as LSD and psilocin, but they are distinguished by their relative brevity. Shulgin "doubt[s] that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitivity to dose, at least one that is active orally." An idiosyncratic effect of the drug, also noted by Shulgin, is its tendency to induce tremors.[1][5][6]

Some users have reported a minor audio distortion with lower dosages. Higher dosages increase the polarity of the distortion. It is defined as being slightly lower in pitch and creating several different effects, such as pitch bend, volume distortion, and rate distortion. As with most DiPT psychedelics, music can become more dissonant and less harmonious. Users have also reported a visual distortion widely comparable to the hallucinogen LSD.

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

Pharmacodynamics

4-HO-DiPT activities
Target
Affinity
(Ki, nM)
5-HT1A 5,700–>10,000
3,900 (
Emax
Tooltip maximal efficacy)
5-HT1B >10,000
5-HT1D 1,860
5-HT1E >10,000
5-HT1F ND
5-HT2A 120–922 (Ki)
6.82–334 (EC50)
74–106% (Emax)
5-HT2B 85 (Ki)
5.12–460 (EC50)
55–110% (Emax)
5-HT2C 2.8–>10,000 (Ki)
1,080–6,442 (EC50)
72–104% (Emax)
5-HT3 ND
5-HT4 ND
5-HT5A >10,000
5-HT6 >10,000
5-HT7 >10,000
α1A >12,000
α1B, α1D ND
α2A 15,000
α2B, α2C >10,000
β1–β3 ND
D3
 >25,000
D5
 >10,000
H1
 9,800–>10,000
H2
 >10,000
H4
 ND
M3
 ND
M4
 1,725
M5
 ND
I1
 ND
σ1 816–1,063
σ2 2,215
TAAR1
Tooltip Trace amine-associated receptor 1		 >15,000 (Ki) (mouse)
>15,000 (Ki) (rat)
ND (EC50) (human)
SERTTooltip Serotonin transporter 419–1,800 (Ki)
163–2,400 (
IC50
Tooltip half-maximal inhibitory concentration)
IA (EC50)
NETTooltip Norepinephrine transporter 11,000 (Ki)
46,000 (IC50)
IA (EC50)
DATTooltip Dopamine transporter >26,000 (Ki)
>100,000 (IC50)
IA (EC50)
Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs: [7][8][9][10][11][12][13]

4-HO-DiPT acts as an

trace amine-associated receptor 1 (TAAR1).[7][13]

Pharmacokinetics

The pharmacokinetics of 4-HO-DiPT have been studied.[11]

4-HO-DiPT Powder
4-HO-DiPT powder.

Finland

Scheduled in government decree on psychoactive substances banned from the consumer market.[14]

Germany

Scheduled in New Psychoactive Substances Act (NpSG). Use of covered substances is permitted only for industrial and scientific purposes.

Sweden

Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-HO-DiPT as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Mar 1, 2005, in their regulation SFS 2005:26 listed as 4-hydroxi-N,N-diisopropyltryptamin (4-HO-DIPT), making it illegal to sell or possess.[15]

United States

4-HO-DiPT is not scheduled at the federal level in the

Federal Analog Act
.

Florida

"4-Hydroxy-N,N-diisopropyltryptamine" is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.[17]

Research

FT-104 [https://pubchem.ncbi.nlm.nih.gov/compound/162510634

FT-104 (O-glutaryl-4-HO-DiPT), a prodrug to 4-HO-DiPT, has entered double blind, randomized, placebo controlled, phase 1 clinical trials in healthy volunteers at the Royal Adelaide Hospital in Australia for the treatment of postpartum depression and treatment-resistant depression. [18][19][20]

References

  1. ^
    OCLC 38503252
    .
  2. PMID 31917152
    . Table 4 Human potency data for selected hallucinogens. [...]
  3. PMID 29850881
    .
  4. ^ "Erowid 4-HO-DiPT Vault : Dosage". www.erowid.org. Retrieved 8 April 2023.
  5. ^ "4-Hydroxy-DIPT". Erowid.
  6. ^ "Tihkal 4-HO-DIPT entry".
  7. ^
    PMID 27216487
    .
  8. ^
    PMID 33860183
    .
  9. ^
    PMID 36669875
    .
  10. ^
    PMID 37082754
    .
  11. ^
    PMID 38758589
    .
  12. ^
    PMID 33860179
    .
  13. ^
    PMID 26791601
    .
  14. ^ "FINLEX ® - Säädökset alkuperäisinä: Valtioneuvoston asetus kuluttajamarkkinoilta… 1130/2014". www.finlex.fi. Retrieved 8 April 2023.
  15. ^ "Svensk författningssamling" [Swedish Code of Statutes] (PDF) (in Swedish). Archived from the original (PDF) on 29 September 2013. Retrieved 25 September 2013.
  16. ^ "21 CFR — SCHEDULES OF CONTROLLED SUBSTANCES §1308.11 Schedule I." Archived from the original on 27 August 2009. Retrieved 17 December 2014.
  17. ^ "Statutes & Constitution :View Statutes : Online Sunshine". leg.state.fl.us. Retrieved 8 April 2023.
  18. ^ "Field Trip Announces First Dosings in Phase I Clinical Study of FT-104" (Press release). 21 July 2022.
  19. ^ "An Inside Look into Field Trip's Next-Generation Psychedelic, FT-104". 11 August 2022.
  20. ^ "WIPO - Search International and National Patent Collections". patentscope.wipo.int. Retrieved 8 April 2023.
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