Diethyltryptamine

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Diethyltryptamine
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • N,N-diethyl-2-(1H-indol-3-yl)ethan-2-amine
JSmol)
Melting point169 to 171 °C (336 to 340 °F)
  • CCN(CC)CCC1=CNC2=C1C=CC=C2
  • InChI=1S/C14H20N2/c1-3-16(4-2)10-9-12-11-15-14-8-6-5-7-13(12)14/h5-8,11,15H,3-4,9-10H2,1-2H3 checkY
  • Key:LSSUMOWDTKZHHT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

DET, also known under its chemical name N,N-diethyltryptamine and as T-9,

mg, without the aid of MAO inhibitors
, and the effects last for about 2–4 hours.

Chemistry

DET is an analogue of the common tryptamine hallucinogen N,N-Dimethyltryptamine or DMT.

Pharmacology

The mechanism of action is thought to be serotonin receptor agonism, much like other classic psychedelics.[3]

DET is sometimes preferred over DMT because it can be taken orally, whereas DMT cannot. This is because the enzyme monoamine oxidase degrades DMT into an inactive compound before it is absorbed. To overcome this, it must be administered in a different manner, i.e. intravenously, intramuscularly, by inhalation, by insufflation, rectally, or by ingestion along with an inhibitor of monoamine oxidase. Because DET has ethyl groups attached to its nitrogen atom, monoamine oxidase is unable to degrade it. This is also true for many other tryptamines with larger nitrogen substituents.

Biochemistry

Although DET is a

4-HO-DMT (Psilocin). Isolation of the alkaloids resulted in 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.[4]

Psychosis model

Early studies of DET as well as other psychedelics were focused on their presumed

pharmacological
understanding, this belief has been dismissed by most researchers.

Legal status

Internationally DET is a Schedule I drug under the Convention on Psychotropic Substances.[7]

Australia

DET is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015).[8] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.

See also

References

  1. ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
  2. ^ "Erowid DET Vault : Chemistry". Retrieved 2008-01-08.
  3. PMID 5306645
    .
  4. S2CID 43308695
    .
  5. ^ Böszörmenyi Z (1960). "Psilocybin and diethyltryptamine: Two tryptamine hallucinogens". Neuro-psychopharm. 2: 226–9.
  6. PMID 5839429
    .
  7. ^ International Narcotics Control Board (August 2003). "List of psychotropic substances under international control" (PDF). Archived (PDF) from the original on 2 March 2007. Retrieved 30 March 2007.
  8. ^ "Poisons Standard". Federal Register of Legislation. Australian Government. October 2015.

External links

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