4-PrO-DMT
Source: Wikipedia, the free encyclopedia.
Chemical compound
4-Propionoxy-N,N-dimethyltryptamine (4-PrO-DMT, or O-Propionylpsilocin) is a synthetic
psychedelic effects, and is believed to act as a prodrug for psilocin.[1] It produces a head-twitch response in mice.[1] It has been sold online as a designer drug since May 2019. It was first identified as a new psychoactive substance in Sweden, in July 2019.[2] A number of related derivatives have been synthesised as prodrugs of psilocin for medical applications.[3]
Recreational use
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Dosage
4-PrO-DMT is reported to be orally active, though its threshold and duration in humans have not been formally studied.
Effects
The effects of 4-PrO-DMT are similar to those of psilocin (4-HO-DMT), as it acts as a prodrug.
Pharmacology
Pharmacodynamics
4-PrO-DMT is theorized to be a serotonergic psychedelic, and is partial agonist of the 5-HT1D, 5-HT1B and 5-HT1A serotonin receptors.
Toxicity
Very little data about the toxicity or pharmacology of 4-PrO-DMT is known. Its chemical structure and pharmacological activity are similar to
psilacetin
, a compound which isn't associated with compulsive use or physical dependence. However, due to lack of research and data, it cannot be definitively concluded that its pharmacological actions in the human body do not differ from those of psilacetin. To date, there have been no reported deaths from 4-PrO-DMT.
See also
- 4-HO-DMT
- 4-AcO-DMT
- 5-MeO-DMT
- FT-104
- Psilocybin
References
- ^ PMID 37082754.
- ISBN 9789294975584.
- PMID 37983270.
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