Liver X receptor beta

Source: Wikipedia, the free encyclopedia.
NR1H2
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_007121
NM_001256647

NM_001285517
NM_001285518
NM_001285519
NM_009473

RefSeq (protein)

NP_001243576
NP_009052
NP_009052.3

NP_001272446
NP_001272447
NP_001272448
NP_033499

Location (UCSC)Chr 19: 50.33 – 50.38 MbChr 7: 44.2 – 44.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Liver X receptor beta (LXR-β) is a member of the

transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).[5]

Function

The liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA) and beta, are known to encode LXR proteins.[5][6]

Structure

Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. The LXRβ core binds DNA via canonical contacts and auxiliary DNA contacts that enhance affinity for the response element.[7]

Interactions

Liver X receptor beta has been shown to

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131408 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060601 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2".
  6. S2CID 27208069
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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.