NFYC
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Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.[5][6][7]
Function
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved
promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit (NFYB), a prerequisite for subunit A (NFYA) association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.[7]
Two
epithelial-mesenchymal transition of human pancreatic islet cells.[8]
Interactions
NFYC has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000066136 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032897 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8921405.
- PMID 9249075.
- ^ a b "Entrez Gene: NFYC nuclear transcription factor Y, gamma".
- PMID 21099261.
- PMID 10446203.
Further reading
- Mantovani R (1999). "The molecular biology of the CCAAT-binding factor NF-Y". Gene. 239 (1): 15–27. PMID 10571030.
- Martinelli R, Heintz N (1994). "H1TF2A, the large subunit of a heterodimeric, glutamine-rich CCAAT-binding transcription factor involved in histone H1 cell cycle regulation". Mol. Cell. Biol. 14 (12): 8322–32. PMID 7969168.
- Nakshatri H, Bhat-Nakshatri P, Currie RA (1997). "Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox". J. Biol. Chem. 271 (46): 28784–91. PMID 8910521.
- Dmitrenko V, Garifulin O, Kavsan V (1997). "Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor". Gene. 197 (1–2): 161–3. PMID 9332362.
- Currie RA (1998). "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y)". J. Biol. Chem. 272 (49): 30880–8. PMID 9388234.
- Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (1999). "Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y". J. Biol. Chem. 274 (34): 24270–9. PMID 10446203.
- Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K (2001). "Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response". Mol. Cell. Biol. 21 (4): 1239–48. PMID 11158310.
- Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K (2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell Sci. 114 (Pt 8): 1533–44. PMID 11282029.
- Chen F, Ogawa K, Liu X, Stringfield TM, Chen Y (2002). "Repression of Smad2 and Smad3 transactivating activity by association with a novel splice variant of CCAAT-binding factor C subunit". Biochem. J. 364 (Pt 2): 571–7. PMID 12023901.
- Romier C, Cocchiarella F, Mantovani R, Moras D (2003). "The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y". J. Biol. Chem. 278 (2): 1336–45. PMID 12401788.
- Salsi V, Caretti G, Wasner M, Reinhard W, Haugwitz U, Engeland K, Mantovani R (2003). "Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function". J. Biol. Chem. 278 (9): 6642–50. PMID 12482752.
- Hirose T, Sowa Y, Takahashi S, Saito S, Yasuda C, Shindo N, Furuichi K, Sakai T (2003). "p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y". Oncogene. 22 (49): 7762–73. S2CID 1826456.
- Chattopadhyay C, Hawke D, Kobayashi R, Maity SN (2004). "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro". Nucleic Acids Res. 32 (12): 3632–41. PMID 15243141.
- Wang B, Gao C, Ponder KP (2005). "C/EBPbeta contributes to hepatocyte growth factor-induced replication of rodent hepatocytes". J. Hepatol. 43 (2): 294–302. PMID 15922473.
External links
- NFYC+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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