KLF2
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| Location (UCSC) | Chr 19: 16.32 – 16.33 Mb | Chr 8: 73.07 – 73.08 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a
Discovery
Erythroid Krüppel-like Factor (
KLF2, initially called lung Krüppel-like Factor due to its high expression in the adult mouse lung, was first isolated in 1995 by using the
Structure
The main feature of the KLF family is the presence of three highly conserved
KLF2 also exhibits these structural features. The
Gene expression
KLF2 was first discovered, and is highly expressed in, the adult mouse
It is expressed as early as embryonic day 9.5 in the endothelium.KLF2 has a particularly interesting expression profile in erythroid cells. It is minimally expressed in the primitive and fetal definitive erythroid cells, but is highly expressed in adult definitive erythroid cells, particularly in the
Mouse knockout
Due to embryonic lethality in KLF2-deficient embryos, it is difficult to examine the role of KLF2 in normal
Function
Lung development
Lung buds removed from KLF2-deficient mouse embryos and cultured from normal
Embryonic erythropoiesis
KLF2 is now believed to play an important role in embryonic erythropoiesis, specifically in regulating embryonic and
The role of KLF2 in human β-like globin gene expression was further elucidated by transfection of a murine KLF2-deficient embryo with the human β-globin locus. It was found that KLF2 was important for ε-globin (found in embryonic hemoglobin) and γ-globin (found in fetal hemoglobin) gene expression. However, as before, KLF2 plays no role in adult β-globin gene expression; this is regulated by EKLF.[15]
However, KLF2 and EKLF have been found to interact in embryonic erythropoiesis.
Endothelial physiology
KLF2 expression is induced by fluid laminar flow shear stress, as is caused by blood flow in normal endothelium.[19][20]
This activates
, which also induces KLF2 expression. KLF2 then has four key functions in endothelium:- By inhibiting activation of leukocyteactivation and hence decreasing inflammation
- It upregulates thromboticeffect
- Through the upregulation of NOS3, as well as vasodilatoryeffect
- KLF2 also inhibits angiogenic effect[21]
Thus KLF2 has an important role in regulating normal endothelium physiology. It is hypothesized that
T-cell differentiation
KLF2 has an important function in
Adipogenesis
KLF2 is a
See also
- Krüppel-like factors
- Erythroid Krüppel-like factor
- Zinc finger transcription factors
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000127528 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055148 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 20878426.
- PMID 10458913.
- ^ PMID 17904406.
- PMID 16380451.
- S2CID 4300395.
- .
- ^ PMID 7565748.
- ^ Palis J, Kinglsey P, Stoeckert CJ. "Gene 16598: Klf2 (kruppel-like factor 2 (lung))". ErythonDB. Archived from the original on 2013-10-29. Retrieved 2013-10-28.
- PMID 9367982.
- PMID 10409672.
- ^ PMID 15947087.
- PMID 17675555.
- PMID 21610079.
- PMID 22566683.
- PMID 12176889.
- ^ PMID 22818581.
- PMID 17585076.
- PMID 22581916.
- PMID 16855590.
- PMID 12426306.
External links
- KLF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- KLF2 human gene location in the UCSC Genome Browser.
- KLF2 human gene details in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.