TLX3
| TLX3 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 5: 171.31 – 171.31 Mb | Chr 11: 33.15 – 33.15 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.[5][6][7]
RNX (HOX11L2, TLX3) belongs to a family of orphan
homeodomain (Dear et al., 1993).[supplied by OMIM][7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164438 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040610 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 85323468.
- S2CID 35224759.
- ^ a b "Entrez Gene: TLX3 T-cell leukemia homeobox 3".
Further reading
- Dear TN, Sanchez-Garcia I, Rabbitts TH (1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4431–5. PMID 8099440.
- Bernard OA, Busson-LeConiat M, Ballerini P, et al. (2002). "A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia". Leukemia. 15 (10): 1495–504. S2CID 32493784.
- Ballerini P, Blaise A, Busson-Le Coniat M, et al. (2002). "HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis". Blood. 100 (3): 991–7. S2CID 16589332.
- Matera I, Bachetti T, Cinti R, et al. (2003). "Mutational analysis of the RNX gene in congenital central hypoventilation syndrome". Am. J. Med. Genet. 113 (2): 178–82. PMID 12407709.
- Mauvieux L, Leymarie V, Helias C, et al. (2003). "High incidence of Hox11L2 expression in children with T-ALL". Leukemia. 16 (12): 2417–22. S2CID 20611777.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Berger R, Dastugue N, Busson M, et al. (2003). "t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH)". Leukemia. 17 (9): 1851–7. S2CID 24379766.
- Cavé H, Suciu S, Preudhomme C, et al. (2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951". Blood. 103 (2): 442–50. PMID 14504110.
- Su XY, Busson M, Della Valle V, et al. (2004). "Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia". Genes Chromosomes Cancer. 41 (3): 243–9. S2CID 19782389.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Ballerini P, Busson M, Fasola S, et al. (2005). "NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance". Leukemia. 19 (3): 468–70. S2CID 27045652.
- Gottardo NG, Jacoby PA, Sather HN, et al. (2005). "Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols". Leukemia. 19 (9): 1705–8. PMID 15990867.
- Borghini S, Vargiolu M, Di Duca M, et al. (2006). "Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia". Mol. Cancer Res. 4 (9): 635–43. PMID 16966433.
- Nagel S, Scherr M, Kel A, et al. (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1". Cancer Res. 67 (4): 1461–71. PMID 17308084.
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