GATA5

Transcription factor GATA-5 is a protein that in humans is encoded by the GATA5 gene.^[5][6]

Function

The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.^[6]

Role in development

Gata5 is a transcription factor. Gata5 regulates the proper development of the heart. Early in embryo development, Gata5 helps in making sure that there are enough heart muscle precursor cells produced to differentiate into the final myocardial cells. It also regulates other genes that are crucial to successful heart development.

• GATA transcription factor

References

Further reading

• Kakita T, Hasegawa K, Morimoto T, Kaburagi S, Wada H, Sasayama S (November 1999). "p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene". The Journal of Biological Chemistry. 274 (48): 34096–102.
  PMID 10567378
  .
• Krasinski SD, Van Wering HM, Tannemaat MR, Grand RJ (July 2001). "Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha". American Journal of Physiology. Gastrointestinal and Liver Physiology. 281 (1): G69–84.
  S2CID 292507
  .
• van Wering HM, Huibregtse IL, van der Zwan SM, de Bie MS, Dowling LN, Boudreau F, Rings EH, Grand RJ, Krasinski SD (August 2002). "Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter". The Journal of Biological Chemistry. 277 (31): 27659–67.
  PMID 12011060
  .
• Benchabane H, Wrana JL (September 2003). "GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations". Molecular and Cellular Biology. 23 (18): 6646–61.
  PMID 12944489
  .
• Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y,
  PMID 14612389
  .
• Divine JK, Staloch LJ, Haveri H, Jacobsen CM, Wilson DB, Heikinheimo M, Simon TC (November 2004). "GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha". American Journal of Physiology. Gastrointestinal and Liver Physiology. 287 (5): G1086–99.
  S2CID 25481694
  .
• Guo M, Akiyama Y, House MG, Hooker CM, Heath E, Gabrielson E, Yang SC, Han Y, Baylin SB, Herman JG, Brock MV (December 2004). "Hypermethylation of the GATA genes in lung cancer". Clinical Cancer Research. 10 (23): 7917–24.
  PMID 15585625
  .
• Wakana K, Akiyama Y, Aso T, Yuasa Y (September 2006). "Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis". Cancer Letters. 241 (2): 281–8.
  PMID 16337738
  .
• Guo M, House MG, Akiyama Y, Qi Y, Capagna D, Harmon J, Baylin SB, Brock MV, Herman JG (November 2006). "Hypermethylation of the GATA gene family in esophageal cancer". International Journal of Cancer. 119 (9): 2078–83.
  PMID 16823849
  .

External links

• GATA5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

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