TFAP4
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Location (UCSC) | Chr 16: 4.26 – 4.27 Mb | Chr 16: 4.36 – 4.38 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.[5]
Function
Transcription factor AP4 is a member of the
basic helix-loop-helix (bHLH) transcription factors
, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000090447 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005718 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)".
Further reading
- Hu YF, Lüscher B, Admon A, et al. (1991). "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity". Genes Dev. 4 (10): 1741–52. PMID 2123466.
- Mermod N, Williams TJ, Tjian R (1988). "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro". Nature. 332 (6164): 557–61. S2CID 4340282.
- Ou SH, Garcia-Martínez LF, Paulssen EJ, PMID 7933101.
- Lewis TB, Wood S, Michaelis EK, et al. (1996). "Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24". Genomics. 32 (1): 131–3. PMID 8786101.
- Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene". Mol. Endocrinol. 12 (2): 233–47. PMID 9482665.
- King-Jones K, Korge G, Lehmann M (1999). "The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4". J. Mol. Biol. 291 (1): 71–82. PMID 10438607.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" (PDF). Nature. 432 (7020): 988–94. S2CID 4362044.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. PMID 17081983.
External links
- TFAP4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.