Retinoic acid receptor beta
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Retinoic acid receptor beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2) is a nuclear receptor that in humans is encoded by the RARB gene.[5][6]
Function
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of
cervical carcinoma preneoplastic lesions.[7] The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined.[5]
Epigenetics
The Retinoic acid receptor beta aberrant promoter DNA hypermethylation has been observed associated with cancer onset/progression. Indeed, this improper epigenetic phenomenon has been observed in women affected by Vulvar Squamous cell carcinoma arose from vulver lichen sclerosus.[8] Methylation of the Retinoic acid receptor beta promoter may be a marker of cancer risk in patients affected by this disease.[8]
Interactions
Retinoic acid receptor beta has been shown to
NR4A2.[9]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000077092 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017491 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: RARB retinoic acid receptor, beta".
- S2CID 23090420.
- S2CID 24986454.
- ^ PMID 29898214.
- PMID 7705655.
Further reading
- Dejean A, de Thé H (Jun 1990). "Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma". Molecular Biology & Medicine. 7 (3): 213–22. PMID 2170809.
- Sun SY (Jan 2004). "Retinoic acid receptor beta and colon cancer". Cancer Biology & Therapy. 3 (1): 87–8. S2CID 42332707.
- Saba N, Jain S, Khuri F (2004). "Chemoprevention in lung cancer". Current Problems in Cancer. 28 (5): 287–306. PMID 15375805.
- Klein O, Grignon Y, Civit T, Auque J, Marchal JC (Sep 2005). "[Methylation status of RARbeta gene promoter in low and high grade cerebral glioma. Comparison with normal tissue. Immuno-histochemical study of nuclear RARbeta expression in low and high grade cerebral glioma cells. Comparison with normal cells. 48 tumors]". Neuro-Chirurgie. 51 (3–4 Pt 1): 147–54. PMID 16389900.
- Katahira M, Knegtel RM, Boelens R, Eib D, Schilthuis JG, van der Saag PT, Kaptein R (Jul 1992). "Homo- and heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure elements". Biochemistry. 31 (28): 6474–80. PMID 1321662.
- Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA (Sep 1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Molecular Endocrinology. 6 (9): 1468–78. S2CID 24291055.
- van der Leede BJ, Folkers GE, Kruyt FA, van der Saag PT (Oct 1992). "Genomic organization of the human retinoic acid receptor beta 2". Biochemical and Biophysical Research Communications. 188 (2): 695–702. PMID 1332705.
- Prentice A, Matthews CJ, Thomas EJ, Redfern CP (May 1992). "The expression of retinoic acid receptors in cultured human endometrial stromal cells and effects of retinoic acid". Human Reproduction. 7 (5): 692–700. PMID 1379266.
- Shen S, Kruyt FA, den Hertog J, van der Saag PT, Kruijer W (1992). "Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness". DNA Sequence. 2 (2): 111–9. PMID 1663808.
- de Thé H, Vivanco-Ruiz MM, Tiollais P, Stunnenberg H, Dejean A (Jan 1990). "Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene". Nature. 343 (6254): 177–80. S2CID 4314508.
- Hoffmann B, Lehmann JM, Zhang XK, Hermann T, Husmann M, Graupner G, Pfahl M (Nov 1990). "A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter". Molecular Endocrinology. 4 (11): 1727–36. PMID 2177841.
- de Thé H, Marchio A, Tiollais P, Dejean A (1988). "A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma". Nature. 330 (6149): 667–70. S2CID 4327614.
- Brand N, Petkovich M, Krust A, Chambon P, de Thé H, Marchio A, Tiollais P, Dejean A (Apr 1988). "Identification of a second human retinoic acid receptor". Nature. 332 (6167): 850–3. S2CID 4349193.
- Benbrook D, Lernhardt E, Pfahl M (Jun 1988). "A new retinoic acid receptor identified from a hepatocellular carcinoma". Nature. 333 (6174): 669–72. S2CID 4313063.
- Dejean A, Bougueleret L, Grzeschik KH, Tiollais P (1986). "Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma". Nature. 322 (6074): 70–2. S2CID 4355348.
- Si SP, Tsou HC, Lee X, Peacocke M (Jul 1995). "Effect of cellular senescence and retinoic acid on the expression of cellular retinoic acid binding proteins in skin fibroblasts". Experimental Cell Research. 219 (1): 243–8. PMID 7628539.
- Houle B, Pelletier M, Wu J, Goodyer C, Bradley WE (Jan 1994). "Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines". Cancer Research. 54 (2): 365–9. PMID 8275470.
- Knegtel RM, Katahira M, Schilthuis JG, Bonvin AM, Boelens R, Eib D, van der Saag PT, Kaptein R (Jan 1993). "The solution structure of the human retinoic acid receptor-beta DNA-binding domain". Journal of Biomolecular NMR. 3 (1): 1–17. S2CID 24063437.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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