TFCP2
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| Location (UCSC) | Chr 12: 51.09 – 51.17 Mb | Chr 15: 100.4 – 100.45 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.[5][6]
TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1.[7] LSF also acts as an oncogene in hepatocellular carcinoma.[8] LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).[9]
Along with its main
epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.[8][10] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death.[8][10][11]
Interactions
TFCP2 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000135457 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009733 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8157699.
- ^ "Entrez Gene: TFCP2 transcription factor CP2".
- PMID 19622726.
- ^ PMID 20404171.
- PMID 22167195.
- ^ PMID 22679558.
- PMID 22396589.
- PMID 9685356.
- PMID 11865070.
Further reading
- Lim LC, Swendeman SL, Sheffery M (Feb 1992). "Molecular cloning of the alpha-globin transcription factor CP2". Molecular and Cellular Biology. 12 (2): 828–35. PMID 1732747.
- Jane SM, Nienhuis AW, Cunningham JM (Jan 1995). "Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein". The EMBO Journal. 14 (1): 97–105. PMID 7828600.
- Shirra MK, Zhu Q, Huang HC, Pallas D, Hansen U (Aug 1994). "One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs". Molecular and Cellular Biology. 14 (8): 5076–87. PMID 8035790.
- Yoon JB, Li G, Roeder RG (Mar 1994). "Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro". Molecular and Cellular Biology. 14 (3): 1776–85. PMID 8114710.
- Margolis DM, Somasundaran M, Green MR (Feb 1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of Virology. 68 (2): 905–10. PMID 8289393.
- Cunningham JM, Vanin EF, Tran N, Valentine M, Jane SM (Nov 1995). "The human transcription factor CP2 (TFCP2), a component of the human gamma-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene". Genomics. 30 (2): 398–9. PMID 8586452.
- Romerio F, Gabriel MN, Margolis DM (Dec 1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". Journal of Virology. 71 (12): 9375–82. PMID 9371597.
- Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. PMID 9685356.
- Bing Z, Reddy SA, Ren Y, Qin J, Liao WS (Aug 1999). "Purification and characterization of the serum amyloid A3 enhancer factor". The Journal of Biological Chemistry. 274 (35): 24649–56. PMID 10455131.
- Coull JJ, Romerio F, Sun JM, Volker JL, Galvin KM, Davie JR, Shi Y, Hansen U, Margolis DM (Aug 2000). "The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1". Journal of Virology. 74 (15): 6790–9. PMID 10888618.
- Zhou W, Clouston DR, Wang X, Cerruti L, Cunningham JM, Jane SM (Oct 2000). "Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4". Molecular and Cellular Biology. 20 (20): 7662–72. PMID 11003662.
- Rodda S, Sharma S, Scherer M, Chapman G, Rathjen P (Feb 2001). "CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors". The Journal of Biological Chemistry. 276 (5): 3324–32. PMID 11073954.
- Zheng JB, Zhou YH, Maity T, Liao WS, Saunders GF (Oct 2001). "Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1". Nucleic Acids Research. 29 (19): 4070–8. PMID 11574690.
- Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (Mar 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology. 22 (6): 1936–46. PMID 11865070.
- He G, Margolis DM (May 2002). "Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat". Molecular and Cellular Biology. 22 (9): 2965–73. PMID 11940654.
- Peters LM, Anderson DW, Griffith AJ, Grundfast KM, San Agustin TB, Madeo AC, Friedman TB, Morell RJ (Nov 2002). "Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28". Human Molecular Genetics. 11 (23): 2877–85. PMID 12393799.
- Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI (Feb 2003). "Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease". American Journal of Medical Genetics Part B. 117B (1): 114–7. S2CID 24087609.
- Chae JH, Kim CG (Feb 2003). "CP2 binding to the promoter is essential for the enhanced transcription of globin genes in erythroid cells". Molecules and Cells. 15 (1): 40–7. PMID 12661759.