ETS transcription factor family
| Ets-domain | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||
In the field of
Subfamilies
The ETS (Erythroblast Transformation Specific)family is divided into 12 subfamilies, which are listed below:[4]
| Subfamily | Mammalian family members | Invertebrate orthologs |
|---|---|---|
| ELF | ELF1, ELF2 (NERF), ELF4 (MEF) | |
| ELG | GABPα | ELG |
| ERG | ERG, FLI1, FEV | |
| ERF | ERF (PE2), ETV3 (PE1) | |
| ESE | ELF3 (ESE1/ESX), ELF5 (ESE2), ESE3 (EHF) | |
| ETS | ETS1, ETS2 | POINTED |
| PDEF | SPDEF (PDEF/PSE) | |
| PEA3 | ETV4 (PEA3/E1AF), ETV5 (ERM), ETV1 (ER81) | |
| ER71 | ETV2 (ER71) | |
| SPI | SPI1 (PU.1), SPIB, SPIC | |
| TCF | ELK1, ELK4 (SAP1), ELK3 (NET/SAP2) | LIN |
| TEL | ETV6 (TEL), ETV7 (TEL2) | YAN |
Structure
All ETS (Erythroblast Transformation Specific) family members are identified through a highly conserved
Other domains are also present and vary from ETS member to ETS member, including the Pointed domain, a subclass of the SAM domain family.
Function
The ETS family is present throughout the body and is involved in a wide variety of functions including the regulation of cellular differentiation, cell cycle control, cell migration, cell proliferation, apoptosis (programmed cell death) and angiogenesis.
Multiple ETS factors have been found to be associated with cancer, such as through
In addition, ETS factors, e.g. the vertebrate Etv1 and the invertebrate Ast-1, have been shown to be important players in the specification and differentiation of
Mode of action
Amongst members of the ETS family, there is extensive conservation in the DNA-binding ETS domain and, therefore, a lot of redundancy in DNA binding. It is thought that interactions with other proteins (eg: Modulator of the activity of Ets called Mae) is one way in which specific binding to DNA is achieved. Transcription factor Ets are a site of signalling convergence.[9] ETS factors act as transcriptional
References
Further reading
- Blair DG, Athanasiou M (2000). "Ets and retroviruses - transduction and activation of members of the Ets oncogene family in viral oncogenesis". Oncogene. 19 (55): 6472–81. PMID 11175363.
- Li R, Pei H, Watson DK (2000). "Regulation of Ets function by protein - protein interactions". Oncogene. 19 (55): 6514–23. PMID 11175367.
- Mimeault M (2000). "Structure-function studies of ETS transcription factors". Crit Rev Oncog. 11 (3–4): 227–53. PMID 11358268.
- Oikawa T, Yamada T (2003). "Molecular biology of the Ets family of transcription factors". Gene. 303: 11–34. PMID 12559563.
- Sementchenko VI, Watson DK (2000). "Ets target genes: past, present and future". Oncogene. 19 (55): 6533–48. PMID 11175369.
- Verger A, Duterque-Coquillaud M (2002). "When Ets transcription factors meet their partners". BioEssays. 24 (4): 362–70. PMID 11948622.
- Nunn M, Seeburg P, Moscovici C, Duesberg P (1983). "Tripartite structure of the avian erythroblastosis virus E26 transforming gene". Nature. 306 (5941): 391–95. S2CID 4302399.