TCF3
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a
Notch signaling) expression.[8]
Function
This gene encodes a member of the E protein (class I) family of
T lymphocyte development.[5]
This gene regulates many developmental patterning processes such as lymphocyte and central nervous system (CNS) development. E proteins are involved in the development of lymphocytes.[11] They initiate transcription by binding to regulatory E-box sequences on target genes.
Clinical significance
Deletion of this gene or diminished activity of the encoded protein may play a role in
lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1 and t(17;19), with HLF),[12] childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384).[5]
Interactions
TCF3 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000071564 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020167 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: TCF3".
- PMID 2308859.
- S2CID 39661371.
- ^ E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment
- PMID 17467953.
- PMID 25564305.
- PMID 11861605.
- PMID 11784864.
- ^ PMID 16407974.
- ^ PMID 12435739.
- PMID 8918463.
- PMID 9525934.
- ^ PMID 9242638.
- PMID 9199284.
- PMID 8628307.
- PMID 10781029.
- PMID 9184158.
- PMID 1325437.
- PMID 8159721.
- PMID 10749989.
- PMID 10497239.
Further reading
- LeBrun DP (May 2003). "E2A basic helix-loop-helix transcription factors in human leukemia". Frontiers in Bioscience. 8 (1–3): s206–22. PMID 12700034.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.