Hepatocyte nuclear factor 4

HNF4 (Hepatocyte Nuclear Factor 4) is a

HNF4 was originally classified as an orphan receptor that exhibits constitutive transactivation activity apparently by being continuously bound to a variety of fatty acids.^[2][3] The existence of a ligand for HNF4 has been somewhat controversial, but linoleic acid (LA) has been identified as the endogenous ligand of native HNF4 expressed in mouse liver; the binding of LA to HNF4 is reversible.^[4]

The ligand binding domain of HNF4, as with other nuclear receptors, adopts a canonical alpha helical sandwich

Mutations in the HNF4A gene have been linked to maturity onset diabetes of the young 1 (MODY1).^[8]

This seems to be caused by HNF4-a's [1] role in the synthesis of

• Hepatocyte nuclear factors
• Hepatocyte nuclear factor 4A

References

External links

• Hepatocyte+Nuclear+Factor+4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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