MTA2
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| Location (UCSC) | Chr 11: 62.59 – 62.6 Mb | Chr 19: 8.92 – 8.93 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.[5][6]
MTA2 is the second member of the MTA family of genes.
Discovery
MTA2 was initially recognized as an MTA1 like 1 gene, named MTA1-L1, from a large scale sequencing of randomly selected clones from human
Gene and spliced variants
MTA2 is localized on chromosome 11q12-q13.1 in human and on 19B in mice. The 8.6-kb long human MTA2 gene contains 20 exons and seven transcripts inclusive of three protein-coding transcripts but predicted to code for two polypeptides of 688 amino acids and 495 amino acids.[13] The remaining four MTA2 transcripts are non-coding RNA transcripts ranging from 532-bp to 627-bp. The murine Mta2 consists of a 3.1-kb protein-coding transcript to code a protein of 668 amino acids, and five non-coding RNAs transcripts, ranging from 620-bp to 839-bp.
Structure
Amino acid sequence of MTA2 shares 68.2% homology with MTA1’s sequence. MTA2 domains include, a BAH (Bromo-Adjacent Homology), an ELM2 (egl-27 and MTA1 homology), a SANT domain (SWI, ADA2, N-CoR, TFIIIB-B), and a GATA-like zinc finger.[14][15][16] MTA2 is acetylated at lysine 152 within the BAH domain[17]
Function
This gene encodes a protein that has been identified as a component of
MTA2 inhibits estrogen receptor-transactivation functions, and participates in the development of hormones independent of breast cancer cells.[11] The MTA2 participate in the circadian rhythm through CLOCK-BMAL1 complex. MTA2 inhibits the expression of target genes owing to its ability to interact with chromatin remodeling complexes, and modulates pathways involved in cellular functions, including invasion, apoptosis, epithelial-to-mesenchymal transition, and growth of normal and cancer cells[9][11]
Regulation
Expression of MTA2 is stimulated by
Targets
MTA2 deacetylates the
Interactions
MTA2 has been shown to
Notes
Wikidata Q28273245 . |
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000149480 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071646 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 9929979.
- ^ a b "Entrez Gene: MTA2 metastasis associated 1 family, member 2".
- ^ PMID 10444591.
- ^ )
- ^ PMID 25344801.
- PMID 25348751.
- ^ PMID 25394532.
- ^ S2CID 20705099.
- PMID 26869315.
- PMID 23791785.
- PMID 24920672.
- PMID 25352341.
- PMID 24468085.
- PMID 24010737.
- PMID 14527417.
- PMID 21447808.
- PMID 24969834.
- PMID 20124483.
- PMID 21566225.
- PMID 25332146.
- PMID 16645043.
- S2CID 4300392.
- PMID 18353770.
- PMID 25929737.
- PMID 25453762.
- ^ PMID 12920132.
- PMID 11171972.
- ^ PMID 10444591.
- ^ S2CID 25822700.
- PMID 12493763.
- PMID 12354758.
- PMID 12124384.
External links
- MTA2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.