ISL1
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| Location (UCSC) | Chr 5: 51.38 – 51.39 Mb | Chr 13: 116.43 – 116.45 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the ISL1 gene.[5] [6]
Function
This gene encodes a
islets of Langerhans. In mouse embryos, a deficiency of this gene results in failure to undergo neural tube motor neuron differentiation.[6]
Interactions
ISL1 has been shown to
interact with Estrogen receptor alpha.[7]
Role in cardiac development
ISL1 is a marker for cardiac progenitors of the
endothelial cell lineages.[9][10][11] Research has shown that ISL1 promotes differentiation of cardiac cells and a depletion of ISL1 can respecify the cell fate of nascent cardiomyocytes, such as from ventricular to an atrial identity. [12]
The validity of ISL1 as a marker for cardiac progenitor cells has been questioned since some groups have found no evidence that ISL1 cells serve as cardiac progenitors.[13] Furthermore, ISL1 is not restricted to second heart field progenitors in the developing heart, but also labels cardiac neural crest.[14] This paper supports work from the Vilquin group in 2011, which concluded that ISL1 can represent cells from both neural crest and cardiomyocyte lineages.[15] While it has been demonstrated by multiple groups that ISL1-positive cells can indeed differentiate into all 3 major cell types of the heart, their clinical relevance has been seriously questioned.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000016082 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042258 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 7912209.
- ^ a b "Entrez Gene: ISL1 ISL1 transcription factor, LIM/homeodomain, (islet-1)".
- PMID 11043578.
- PMID 14667410.
- S2CID 31238870.
- PMID 15703750.
- S2CID 801804.
- PMID 29337667.
- PMID 22427341.
- PMID 22394517.
- PMID 20942609.
Further reading
- Larsson LI (November 1998). "On the development of the islets of Langerhans". Microscopy Research and Technique. 43 (4): 284–291. S2CID 19416265.
- Dong J, Asa SL, Drucker DJ (November 1991). "Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1". Molecular Endocrinology. 5 (11): 1633–1641. PMID 1685766.
- Riggs AC, Tanizawa Y, Aoki M, Wasson J, Ferrer J, Rabin DU, et al. (June 1995). "Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM". Diabetes. 44 (6): 689–694. PMID 7789634.
- Wang M, Drucker DJ (March 1994). "The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage". Endocrinology. 134 (3): 1416–1422. PMID 7907017.
- Pfaff SL, Mendelsohn M, Stewart CL, Edlund T, Jessell TM (January 1996). "Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation". Cell. 84 (2): 309–320. S2CID 5780554.
- Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. PMID 8889548.
- Ahlgren U, Pfaff SL, Jessell TM, Edlund T, Edlund H (January 1997). "Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells". Nature. 385 (6613): 257–260. S2CID 4341596.
- Jurata LW, Pfaff SL, Gill GN (February 1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". The Journal of Biological Chemistry. 273 (6): 3152–3157. PMID 9452425.
- Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, et al. (August 1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nature Genetics. 22 (4): 394–399. S2CID 22326394.
- Gay F, Anglade I, Gong Z, Salbert G (October 2000). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Molecular Endocrinology. 14 (10): 1627–1648. PMID 11043578.
- Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I (March 2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. S2CID 4426785.
- Holm P, Rydlander B, Luthman H, Kockum I (June 2004). "Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families". Diabetes. 53 (6): 1584–1591. PMID 15161765.
- Hori Y, Gu X, Xie X, Kim SK (April 2005). "Differentiation of insulin-producing cells from human neural progenitor cells". PLOS Medicine. 2 (4): e103. PMID 15839736.
- Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, et al. (May 2005). "Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development". Development. 132 (10): 2463–2474. PMID 15843409.
- Peng SY, Wang WP, Meng J, Li T, Zhang H, Li YM, et al. (December 2005). "ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1731 (3): 154–159. PMID 16321656.
External links
- ISL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.